Team
Politecnico di Torino was the first Italian Engineering School, founded in the wave of the technical and scientific innovation that gave rise to the most prestigious European polytechnic schools in the mid-19th century. Founded as a School for Engineers in 1859, it then became Regio Politecnico di Torino in 1906. Engineers, architects, designers and urban planners have been trained at Politecnico di Torino for over 160 years with rigor, integrity and high-level standards.
This long ever-changing history has rated Politecnico among the top European technical Universities for education and research, with over 37,000 studentr and a teaching staff of more than 1,000.
ROLE IN THE PROJECT
Project coordination, formulation for the patch ESP, smart carrier development and integration in the patch, drug release test upon US stimulation, surface treatments, design of the patch architecture to modulate mechanical properties and flexibility. WP1 and WP3 leader.
By signing “Scientiae Thesaurus Mirabilis”, King Dinis created the oldest university of the country and one of the oldest in the world. Dated from 1290, the document originated the General Study, recognised in the same year by Pope Nicholas IV. A century after the birth of the nation, the University of Coimbra germinated. It starts operating in Lisbon but, in 1308, it is transferred to Coimbra, alternating between the two cities until 1537, when it is definitely settled in the city of river Mondego.
To study at the University of Coimbra is to pursue the intellectual history of the country in the school that graduated some of the most distinguished personalities of national culture, science and politics.
With over seven centuries, and celebrating this year its 730th anniversary, the University of Coimbra has a unique tangible and intangible heritage, keystone in the scientific culture of Europe and the World, and is a UNESCO World Heritage Site since 2013.
ROLE IN THE PROJECT
Definition of drug therapeutics doses and delivery kinetics, miRNA-EVs transfection and their incorporation into the patch, drug release in vitro test, evaluation of US effect (sonoporation), pluripotent cells for the heart chamber test, WP2 leader.
Sant’Anna School of Advanced Studies is a public university institute - with special autonomy - working in the field of applied sciences: Economics and Management, Law, Political Sciences, Agricultural Sciences and Plant Biotechnology, Medicine, and Industrial and Information Engineering.
The School promotes the internationalization of didactics and research with innovative paths in the fields of university education, scientific research and advanced training.
ROLE IN THE PROJECT
Development of in vitro and in vivo US platforms for the drug release and other US effects (i.e. sonoporation), computational modelling for the mechanical patch response and for in vitro to in vivo translation.
With over 100 years of history, the University of Porto is a leading teaching and scientific research institution in Portugal and worldwide.
Considered the best Portuguese University and one of the best 100 European institutions according to the most important Higher Education rankings, U.Porto combines quality teaching and excellent research with the best academic experience.
ROLE IN THE PROJECT
Definition of clinical requirements and specifications, ethical approval and execution of in vivo test in large animals, definition of minimally invasive procedure for the cardiac patch application.
Health Research in a single and solid institution could be a definition for i3S, but the Institute for Research and Innovation in Health is so much more. The will of three research institutes to build a better future gave rise to a new building housing a new institution driven to face and overcome the most relevant health challenges society faces today such as: aging, infectious diseases, cancer, regenerative medicine and neurodegenerative diseases.
ROLE IN THE PROJECT
3R’s Officer, in vitro efficacy test of the patch incorporating the drug with and without US stimulation, ethical approval and execution of in vivo test in small animals.
Bioinicia is a company with R&D and production expertise in both electrospinning and electrospraying processes. Scientists, engineers, project managers and manufacturing operators all working towards a common goal: to support our partners at all stages of their development.
We have a wide range of experience in developing micro or nanofiber-based membranes and coatings (electrospinning), and in encapsulation of functional ingredients, bioactives, natural extracts and biological materials (electrospraying).
ROLE IN THE PROJECT
Support of POLITO in the definition of ESP parameters and green processes, patch translation at TRL5 under GMP conditions in ISO13485 plant, sterilisation, packaging and shelf life tests, use of clean rooms to incorporate UC miRNA EVs into the electrospun patch, WP5 leader.
Regemat 3D makes available to research and science a technology tailormade designed what born to integrate the advantages of the additive manufacturing with tissue engineering and applied to the regenerative medicine.
The personalized configuration of each bioprinter taking into account the specific application and the support of our engineer team, make possible daily, the achieving of reliable results, which facilitate the path of each research.
ROLE IN THE PROJECT
Translation at TRL5 of REJI technologies and its implementation onto commercial printer, polymeric formulations for UNEW and POLITO.
Corcym is a global medical device company focused on the structural heart area. Corcym offers a complete portfolio of surgical solutions with a heritage spanning more than 50 years, leveraging on a complete and distinctive set of technologies, capabilities and infrastructure.
Our vision is to become the leading company dedicated to Heart Surgeons and their Patients by providing the best solutions to fight structural heart disease.
ROLE IN THE PROJECT
Interaction with UP for the definition of the clinical requirement, design of the kit for minimally invasive surgery, final patch design, sterilisation, design dossier file, dossier template for regulatory, WP7 leader.
Cellogic GmbH was spun off from the Berlin-Brandenburg Center for Regenerative Therapies - BCRT - as part of the BMBF-funded project Competence Center for Advanced Therapy Medicinal Product Development - CC-ATMP.
It currently has five employees and offers consulting services in the early phase of ATMP development projects. In addition to questions from regulatory affairs, clinical development and quality management, one focus is in particular on health economic analyzes for a targeted preparation of the translation process.
ROLE IN THE PROJECT
Continuous benchmarking, identification of promising patient cohorts, coordination of cost-assessment, development of health-economic models and calculation of price-ceilings for REBORN patch.
beWarrant (BEWG) is a branch of the Italian company Warrant Hub SpA, a privately held consultancy services company that provides full-spectrum consulting in business finance. Warrant Hub has been active since 1995, growing over the years to become a leader in its sector today. WH Business Units work in synergy with its Innovation Lab to give their clients the best support tools for the success of their business initiatives and to assist them in the preparation and management of strategic projects: business projects, research projects, training and technology transfer activities, under National and International support frameworks.
The European Funding Division (EFD) team provides consultancy, training and support on European Funding opportunities, and in the preparation, negotiation and management of European Proposals, particularly on H2020 calls. EFD offers also support for communication and dissemination activities, and periodically participates into and organizes sectional seminars and networking events with/for industrial associations, SMEs, policy makers, etc. thus having the opportunity to disseminate the project results to relevant audiences.
ROLE IN THE PROJECT
Leader of exploitation, dissemination and communication activities, evaluation of environmental, social and economic impacts of the project. BEWH will strengthen the consortium thanks to its extended network of relevant industrial stakeholders and clusters, WP8 leader.
Warrant Hub S.p.A. is a privately held consultancy services company that provides full-spectrum consulting in business finance. The European Funding Division (EFD) team provides consultancy, training and support on European Funding opportunities, and in the preparation, negotiation and management of European Proposals, particularly on H2020 calls. EFD offers also support for communication and dissemination activities, and periodically participates into and organizes sectional seminars and networking events with/for industrial associations, SMEs, policy makers, etc. thus having the opportunity to disseminate the project results to relevant audiences.
ROLE IN THE PROJECT
Quality and risk management activities, IPR and data management plan, supporting BEWH in business cases development, exploitation and dissemination.
Newcastle University (legally the University of Newcastle upon Tyne) is a UK public research university based in Newcastle upon Tyne, North East England. It has overseas campuses in Singapore and Malaysia. The university is a red brick university and a member of the Russell Group, an association of research-intensive UK universities.
ROLE IN THE PROJECT
Definition of the tissue engineered heart chamber as an advanced in vitro test, development of new materials and new biofabrication processes in order to create the heart chamber, evaluation of the heart chamber, in vitro assessment of patch materials and performance, WP4 leader.
ROLE IN THE PROJECT
Specification, commercialisation and translation at TRL5 of cardiac tissue engineered in vitro model.
